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Search Results for " valosin-containing protein "

Targets Recommended: Others

4

抑制剂 & 化合物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T12236	NMS-859 ZINC169324353	Others	Others
	NMS-859 是一种有效的含 valosin 蛋白 (VCP)/p97 的共价抑制剂，在细胞中存在 60 μM 和 1 mM ATP 的情况下，对野生型 VCP 的 IC50 分别为 0.37 μM 和 0.36 μM。
T9008	NPD8733	Others	Others
	NPD8733 是癌细胞增强的成纤维细胞迁移抑制剂。它是与多种细胞活动 (AAA+) 蛋白家族相关的 ATP 酶的成员，能够与含 valosin 的蛋白 (VCP)/p97特异性结合，对癌症疾病具有潜在的研究价值。
T69679	LC-1028
	LC-1028 is a novel potent selective, covalent and irreversible inhibitor of p97 (valosin-containing protein) with IC50 =33 nM.
T36570	KUS121
	KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cell death, ATP depletion, and upregulation of C/EBP-homologous protein (CHOP) induced by tunicamycin, an inducer of ER stress, in HeLa cells when used at concentrations of 20, 50, and 50 μM, respectively. KUS121 (100 μM) inhibits ATP depletion and cell death induced by oxygen-glucose deprivation (OGD) in rat primary cortical neurons in anin vitromodel of cerebral ischemia.2It red...

化合物

Cat.No: T12236

Synonym: ZINC169324353

Target: Others

Cat.No: T9008

Target: Others

Cat.No: T69679

Cat.No: T36570

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01013	VCP Protein, Human, Recombinant (His) TER ATPase,Transitional Endoplasmic Reticulum ATPase,15S Mg(...	Human	E. coli
	Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. It is necessary for the fragmentation of Golgi stacks during mitosis and their reassembly after mitosis. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin...

重组蛋白

VCP Protein, Human, Recombinant (His)

Cat.No: TMPJ-01013

Species: Human

Expression System: E. coli

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